In general, the Mediation Tool does not require tuning. It is possible that you may exceed the heap limit. If you exceed the heap limit, you can try reducing the amount of open content in the tool. If it happens repeatedly, increase the heap limit.
To increase the heap limit:
Open the eclipse.ini file, which is located in the Mediation Tool’s eclipse folder.
Edit the file by adjusting the -Xmx setting incrementally upwards, and re-launch the Mediation Tool.
Take into account what else is running on the system and consider if there is a risk of exceeding the system limit if you increase this value.